| 1. Depressed mood. | |
| 2. Loss of interest or pleasure in most activities. | |
| 3. Significant weight loss or gain, or change in appetite nearly every day. | |
| 4. Insomnia or hypersomnia. | |
| 5. Psychomotor agitation or retardation (observable by others). | |
| 6. Fatigue or loss of energy. | |
| 7. Feelings of worthlessness or excessive or inappropriate guilt. | |
| 8. Diminished ability to think or concentrate, or indecisiveness. | |
| 9. Recurrent thoughts of death or suicide. | |
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